Click here to read the research document Conducted by Caroline Rae at University of Sydney Australia

The heart of our company is presented on this page. If after reading this you do not choose to supplement your diet with ™ then we have truly failed to do our job. ™ is not only vital for your mental health today but the long term ramifications of neuro-nutrition are only just beginning to be understood.

In 2003 a major study was undertaken by a group of scientists from the University of Sydney to understand the effects of certain amino acids on cognitive function. The test was ethical, and scientifically controlled.   The published results of this study were peer-reviewed, and we think you will agree that is is powerful information.  The study demonstrated that vegetarians who supplemented their diet with a specific amino acid called creatine (a nutrient found in most meat products, but deficient in a typical vegetarian diet) had statistically higher scores on tests of mental function and memory.   What makes this study truly remarkable is that of all the nutritional supplements and herbal products reported to increase mental capacity, creatine is the only one to have shown long-term benefits.  These studies along with other published scientific reports of creatine supplementation in neurodegenerative diseases such as Parkinson’s and Alzheimer’s convinced us of the need for a creatine product that could address the deficiencies in a normal vegetarian diet.  The result of this is ™ a revolutionary creatine supplement that optimizes creatine absorption in the gastro-intestinal tract and improves creatine delivery to the brain.   I would like at this point to introduce you to Dr Don Miller who is a Specialist in Brain Membrane Transfer with a focus on drug delivery at the University of Manitoba. He will dissect the trial and explain how the use of  a specially conjugated ester form of Creatine could truly affect your life today and the possible ramifications on tomorrow.

The study Andrew is referring to is by Caroline Rae and colleagues at the University of Sidney in Sidney Australia.  This study was published in its entirety in 2003 in the Proceedings of the Royal Society, London, Volume 270, pages 2147-2150.  The purpose of the study was to examine the effects of creatine supplementation on cognitive functions in vegetarians.  The rationale for the studies was as follows. It has been shown conclusively in a number of studies that vegetarian diets result in lower levels of creatine.  In fact the plasma levels of creatine in non-vegetarians are about twice as much as that found in vegetarians.   However, most of the studies with creatine have focused on the effects that creatine supplementation has on skeletal muscle, bigger muscles, better physical performance, etc. etc. Several lines of emerging research suggest creatine, at the right doses, has important uses in the other tissues as well.  One such tissue is the brain.  Probably the most telling of the important role for brain creatine comes from studies on mental retardation.  There are many causes of mental retardation, but at least two different forms are due to genetic mutations in the creatine processing pathway.  One involves a genetic mutation that results in a deficiency in the enzyme that is involved in the formation of creatine from its amino acid precursors in the body.  For kids with this mutation, dietary supplementation with very high doses of creatine can have beneficial effects.  In the second form, the genetic deficiency is in the creatine transporter that transports creatine from the blood into the brain.  Unfortunately patients with this form of mental retardation do not respond to creatine supplementation as the problem is not in insufficient production of creatine, it is in insufficient amounts of creatine being delivered to the brain.  These studies show a clear role for creatine in learning and cognitive function. 

Additional evidence for the importance of brain creatine can be found in the recent clinical trials showing creatine supplementation is of benefit in Parkinson’s Disease.  This was part of a large clinical trial sponsored by the National Institutes of Health to identify dietary supplements and herbal products with beneficial effects in neurological diseases.   Together these studies form the backdrop and rationale for the studies of creatine supplementation in vegetarians.

The study by Dr. Rae enrolled 45 vegetarians and randomly divided them into two groups.  Each of the subjects were given two different cognitive function tests, once before starting the study, again at 6 and 12 weeks into the study and then a final time at the conclusion of the study (18 weeks).  The first treatment group was given 5 grams of creatine monohydrate per day for six weeks; the second treatment group was given placebo (i.e. 5 grams of maltodextrin).  After a 6-week washout period, the treatment arms were switched so that the first treatment group now received placebo, and the second treatment group now received creatine monohydrate.  This type of study is called a cross-over study. The study was also blinded.  What this means is that the researchers examining the results of the cognitive tests did not know what the subjects were taking (in other words they were blinded as to the treatments received by the subjects).  

As expected those subjects taking creatine had much higher plasma levels of creatine compared to those taking placebo.  However, more importantly, those subjects consuming creatine supplementation, over a 6-week period, displayed significantly increased intelligence as determined with the cognitive function tests.  This study provides clear prove as to the importance that creatine supplementation can have in the vegetarian diet.   I challenge you to find another supplement or herbal product that can deliver these results in a controlled, blinded, cross-over clinical study format.

 So, knowing the importance that creatine supplementation can have on brain function, the question is not should you take a creatine supplement?, but rather of all the creatine supplements available which creatine supplement is the best?  Most of the creatine supplements available use creatine monohydrate.  Creatine monohydrate is not very water soluble and not easily absorbed in the gastro-intestinal tract.  As a result, people taking creatine monohydrate have to take relatively large amounts (5-20 grams/day) to see the desired effect.  Since most of the creatine in the gastro-intestinal tract is not in solution, the undissolved creatine, before being eliminated in the feces, can act as an osmotic agent, drawing water out of the intestinal cells.  The result of this is a bloated feeling and in extreme cases, diarrhea. 

About 5 years ago, my colleagues and I embarked on a series of studies to improve the oral bioavailability of creatine.  The intent was essentially to create a form of creatine that had better oral absorption than the standard creatine monohydrate that was being used in dietary supplements.  The approach we took was to esterify creatine.  This approach has been used very successfully in the pharmaceutical industry to improve the pharmacokinetic properties of a drug.   We found that the esterified forms of creatine were more water soluble than creatine monohydrate, as much as 40 times more soluble! The importance of this is that creatine can only be absorbed if it is in solution.  Thus, with more creatine in solution, you have improved oral absorption.   Surprisingly, we also found that certain esterified forms of creatine also had the ability to penetrate into cells better than creatine monohydrate.  The importance of this is there is increased efficiency in the delivery of creatine from the blood to the cells.  The lead molecule from these studies is the creatine found in Intellegent Health’s ™.

If you google creatine, you will find a lot of information pertaining to its use to improve muscle function.  You will also find a lot of products that claim to have special forms of creatine in them.  As the person actually listed on the patent application for our form of esterified creatine, I have been surprised at the number of people who claim to have invented and/or developed this compound.  But what was even more of a shock was the number of products that claimed to have certain types of creatine on the label, but upon analysis in my laboratory proved to have none!  My reason for telling you this?  Obviously, I believe in the important function that creatine has, not only for skeletal muscles, but other tissues such as the brain.  I believe ™ is superior creatine product compared to other creatine supplements currently on the market, and I am impressed by the steps that Intelligent Health has taken to ensure that ™, has the highest quality manufacturing and processing available.  

This is important, to your job, your family, your children and your long term health. It is too important not to purchase this product today and to commit to using it for the rest of your life.  I promise you that you will feel better, live longer, you will be less tired and your ability to exceed in everyday day life will be Enhanced…… buy it now.”